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Istradefylline forty mg/working day greater peak degrees and AUC of CYP3A4 substrates in scientific trials. This influence wasn't noticed with istradefylline 20 mg/day. Think about dose reduction of sensitive CYP3A4 substrates.Observe Carefully (1)ribociclib will increase the degree or outcome of triazolam by affecting hepatic/intestinal enzyme CYP